Correlation of creatine phosphokinase (CPK) levels with severity of organophosphate poisoning
DOI:
https://doi.org/10.61581/mjsp.v6i3.347Keywords:
Atropine, Creatine phosphokinase, Creatine kinase, Organophosphorus, Organophosphate, Organothiophosphonate Poisonings, MalathionAbstract
Objective: To determine the correlation of creatine phosphokinase (CPK) levels with the severity of organophosphate poisoning in assessing the prognosis.
Methodology: A cross-sectional study was conducted from January 9, 2025, to July 9, 2025, at the Department of Accident and Emergency, Mayo Hospital, Lahore. A total of 60 patients presenting with organophosphate poisoning were enrolled. The Peradeniya Organophosphate Compound Poisoning Scale (POP) assessed the severity of OP poisoning. Then, blood samples were collected for serum creatine phosphokinase. A comparison of CPK levels between mild to moderate and severe organophosphate poisoning was performed using a paired t-test. To find a correlation between CPK levels and the severity of OP poisoning (POP score), the Pearson correlation coefficient (r) was used.
Results: The mean age was 37.63±13.48 years, with 55.0% of patients being under 40 years old. There were 78.3% males. The mean serum CPK level was 615.95±407.75 (IU/L). Patients with mild to moderate POP scores had a mean CPK level of 515.11 ± 248.65 IU/L, whereas those with severe scores had a significantly higher mean of 1374.33 ± 189.65 IU/L (p < 0.001). Pearson correlation analysis revealed a strong positive correlation between POP severity and CPK levels (r = 0.807, p < 0.001).
Conclusion: Our study concluded that the creatine phosphokinase level is positively correlated with severe organophosphate poisoning, as measured by the POP scale.
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