Relationship of Vitamin D Levels with Simultaneous Occurrence of Periodontal and Cardiac Diseases
DOI:
https://doi.org/10.61581/MJSP.VOL01/01/01Keywords:
Calcium, Cardiac disease, Periodontal disease, Severity, Vitamin DAbstract
Objective: To observe relationship of vitamin D levels with the severity of periodontal disease and also with the occurrence of cardiac diseases.
Methodology: This cross-sectional study conducted at Nishtar institute of dentistry, Multan from March 5th, 2019 to December 1st, 2019. Total 150 subjects were enrolled in the study, of which half were suffering from cardiac and periodontal diseases and one third were only affected by periodontitis. Twenty five subjects were normal. Vitamin D and calcium levels were recorded from the blood samples. Mean and standard deviation were calculated between the groups with 2 sample t- test using SPSS v.23.0. The significance of difference was taken at p?0.05.
Results: Vitamin D levels were 24.98±4.53ng/ml and 41.95±1.42ng/ml in patients with high and low intensity of periodontal disease, rspectively (p=0.22). Calcium levels were 8.43±0.14nmol/L and 8.69±0.28nmol/L in patients with high and low intensity of periodontal disease, rspectively (p=0.437). Among the male cardiac patients, vitamin D levels were 20.96±2.39ng/ml and 41.67±4.78ng/ml in high and low severity of periodontal disease cases (p=0.002), whereas calcium levels were 8.03±0.30nmol/L and 8.95±0.77nmol/L in high and low severity of periodontal disease cases (p=0.075).
Conclusion: Low level of vitamin D has the relationship with the severity of periodontal disease and also with the occurrence of cardiac diseases.
Downloads
References
1. Martelli FS, Martelli M, Rosati C, Fanti E. Vitamin D: relevance in dental practice. Clin Cases Miner Bone Metab. 2014;11(1):15.
2. Verdoia M, Schaffer A, Sartori C, Barbieri L, Cassetti E, Marino P, et al.. Vitamin D deficiency is independently associated with the extent of coronary artery disease. Eur J Clin Invest. 2014;44(7):634-42.
3. Jahani R, Fielding KA, Chen J, Villa CR, Castelli LM, Ward WE, et al. Low vitamin D status throughout life results in an inflammatory prone status but does not alter bone mineral or strength in healthy 3‐month‐old CD‐1 male mice. Mol Nutr Food Res. 2014;58(7):1491-501.
4. Genco RJ, Borgnakke WS. Risk factors for periodontal disease. Periodontol. 2013;62(1):59-94.
5. Johnston B, Fritz P, Ward W. Use of dietary supplements in patients seeking treatment at a periodontal clinic. Nutrients. 2013;5(4):1110-21.
6. Wang Q, Li H, Xie H, Fu M, Guo B, Ding Y, et al. 25-Hydroxyvitamin D3 attenuates experimental periodontitis through downregulation of TLR4 and JAK1/STAT3 signaling in diabetic mice. J Steroid Biochem Mol Biol. 2013;135:43-50.
7. Zhang X, Meng H, Sun X, Xu L, Zhang L, Shi D, et al. Elevation of vitamin D‐binding protein levels in the plasma of patients with generalized aggressive periodontitis. J Periodont Res. 2013;48(1):74-9.
8. Bashutski JD, Eber RM, Kinney JS, Benavides E, Maitra S, Braun TM, et al. The impact of vitamin D status on periodontal surgery outcomes. J Dent Res. 2011;90(8):1007-12.
9. Griz LH, Bandeira F, Gabbay MA, Dib SA, Carvalho EF .(2014) Vitamin D and diabetes mellitus, 1:1-8.
10. Beveridge LA, Witham MD. Vitamin D and the cardiovascular system. Osteoporosis Int. 2013;24(8):2167-80.
11. Martineau A, Jolliffe D. “Vitamin D and Human Health: from the Gamete to the Grave”: Report on a meeting held at Queen Mary University of London, 2014.
12. Kronenberg HM, Melmed S, Polonsky K, Larsen P. Hormones and disorders of mineral metabolism. Williams Textbook of Endocrinology, 11th ed. Philadelphia Editorial Saunders Elsevier. 2008:1224-69.
13. Garcia MN, Hildebolt CF, Miley DD, Dixon DA, Couture RA, Spearie CL, Langenwalter EM, Shannon WD, Deych E, Mueller C, Civitelli R. One‐year effects of vitamin D and calcium supplementation on chronic periodontitis. J Periodontol. 2011;82(1):25-32.
14. Grant WB, Boucher BJ. Are Hill's criteria for causality satisfied for vitamin D and periodontal disease?. Dermato Endocrinol. 2010;2(1):30-36.
15. Grant WB, Giovannucci E. The possible roles of solar ultraviolet-B radiation and vitamin D in reducing case-fatality rates from the 1918–1919 influenza pandemic in the United States. Dermato-Endocrinol. 2009;1(4):215-19.
16. Bashutski JD, Eber RM, Kinney JS, Benavides E, Maitra S, Braun TM, et al. The impact of vitamin D status on periodontal surgery outcomes. J Dent Res. 2011;90(8):1007-12.
17. Miley DD, Garcia MN, Hildebolt CF, Shannon WD, Couture RA, Anderson Spearie CL, et al. Cross‐sectional study of vitamin D and calcium supplementation effects on chronic periodontitis. J Periodontol. 2009;80(9):1433-39.
18. Intini G, Katsuragi Y, Kirkwood KL, Yang S. Alveolar bone loss: mechanisms, potential therapeutic targets, and interventions. Advance Dent Res. 2014;26(1):38-46.
19. Zhan Y, Samietz S, Holtfreter B, Hannemann A, Meisel P, Nauck M, et al. Prospective study of serum 25-hydroxy vitamin D and tooth loss. J Dental Res. 2014;93(7):639-44.
Downloads
Published
Issue
Section
License
Copyright (c) 2020 Muhammad Amjid Bari, Naghma Perveen, Sohail Fareed, Noorul Ain Arshad, Saima Munir, Khalil Ahmad Khan

This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution (CC-BY) 4.0 License that allows others to share the work with an acknowledgment of the work’s authorship and initial publication in this journal.